Question: Can Vorinostat Help Heartbreak?
Based on the provided notes, there is evidence suggesting that vorinostat may indeed help with heartbreak and emotional recovery from relationship issues. Here are the key points supporting this:
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Vorinostat - Page 9 - Brain Health - LONGECITY reports a user's experience where vorinostat helped reduce the emotional pain associated with a past relationship:
"Unbidden, a memory of the girl I'd dated 5 months before floated to my mind. And for the first time in all those months, I could feel it lose its emotional salience. The pain was dulled. I ran into her a few weeks later, and, for the first time since our first kiss, I wasn't flustered and rendered stupid by her mere proximity."
Source: [1]
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Vorinostat - Page 11 - Brain Health - LONGECITY provides another user's account:
"My best experience so far (same with StevesPetRat) was to get over a serious relationship with not too much pain, I was surprised both of the strong anxiolytic effects I got with 50mg, continuing with a dose every other day for 300mg in total I was in a state that I will probably need more than a couple months to get not thinking about it, been in a low mood."
Source: [2]
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Vorinostat - Page 10 - Brain Health - LONGECITY mentions:
"It seems to have a strong effect in 'dating anxiety' for me, both in asking girls out for a date, and feeling far calmer when my last relationship ended, in a similar fashion to StevesPetRat's description before."
Source: [3]
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Vorinostat/rNootropics - [NSFW] Article on HDAC Inhibitors explains the mechanism:
"When you take an HDAC inhibitor and 'get rid of' a fearful memory, you're actually not getting rid of it, you're downplaying it. The present is prioritized, overshadowing any grossly inflated fear memories."
This mechanism could apply to the emotional pain of heartbreak as well.
Source: [4]
It's important to note that individual experiences may vary, and vorinostat should be used carefully and under proper guidance. The dosage and frequency mentioned in these anecdotes (50-300mg, with varying intervals) should not be taken as medical advice. Always consult with a healthcare professional before using any medication for off-label purposes.